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Most of the side effects are headache, indigestion, back pain, muscle aches, redness and nasal congestion or discharge. All are due to the same effect on PDE5 inhibition, which has the same effects throughout the body.

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Most of these appear quickly, but disappear within a few hours. Generally, most long-lived are back and muscle pain, which can occur up to a day after taking the drug, disappearing within 48 hours.

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It is important to point out that the FDA indicated in that all the drugs used for erectile dysfunction whose main component inhibits PDE5 were related to important ocular disorders that arose from ischemic optic neuropathies. However, the side effect was not directly associated with Cialis. It turns out that most of these patients had anatomical or vascular disorders that predisposed the development of this pathology. Therefore, the use of PDE5 inhibitors simply increased the probability of the development of this lesion. In addition, many of them had other associated secondary diseases such as hypertension, diabetes, lung disorders, etc.

Despite all this, the FDA kept the drug on the market because there was no probable direct relationship between the disorder and the drug. Another important side effect is hearing loss. Many of the drugs with the same mechanism of action, after they came onto the market, were found to be associated with sudden hearing loss.

In the FDA carried out the relevant studies and confirmed this link. What they proposed was to warn the consumer of the possible -but very rare - side effect. A big myth is the "risk" of taking drugs like Tadalafil when you have hypertension. This is not entirely true.

Erectile dysfunction drugs are approved for use in people who are hypertensive. In fact, as mentioned above, it can be used in a type of pulmonary arterial hypertension. However, the real problem - and the reason why you should consult with your doctor - lies in the medications you use to treat hypertension.

Remember that tadalafil, through important cellular processes, can increase the amount of nitric oxide in the smooth muscle cells of the penis, causing vasodilation and increased blood flow. However, there are many patients with hypertension who use nitric derivatives to control their blood pressure.

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This group includes some of the "calcium channel blockers" such as Nifedipine, nitroglycerin, etc. The combination of both drugs can result in a potentially serious adverse effect: severe hypotension. Both drugs can vasodilate your arteries, thus generating a powerful synergistic effect, causing hypotension. That's not all. Tadalafil is also able to inhibit the mechanisms by which nitrates are degraded, allowing your blood pressure medication to remain in the system longer, causing dangerous side effects.

Many people report that they feel palpitations when taking Cialis. This is a regulatory response of your heart to counteract the hypotension generated. However, when both drugs are used together your heart is not able to regulate this response, so it can be deadly.

There are certain signs that you should watch for and see your doctor if you have them. These are:.

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Use: You can use only one pill a day, at least one hour before any sexual activity. It is indistinct if taken with or without food, will not affect its absorption or functioning.

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Remember that this medicine will be between 18 and 24 hours in your system, so it is important to avoid and regulate the use of other medications with nitrates during that time. Dosage: You should always talk to your doctor so that he or she can recommend a personalized treatment. It is normal to start with low doses to avoid possible allergies and to evaluate how you respond to this medicine. If higher doses are needed, please consult your doctor again for a readjustment. Sexual stimulation is necessary: although the medication is in your bloodstream, it will have no effect if you do not have any sexual stimulation.

This medicine is not related to libido or desire.

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It is not an aphrodisiac. It will not help you feel desire for your partner. So if there's no initial stimulation, as in some mental disorders, you won't be able to get an erection even if you take this medicine. Don't drink alcohol: alcohol is also an important vasodilator, so you will be enhancing its effect. But the most important thing is that it can interrupt your metabolism at the liver level, prolonging the half-life of the drug, causing more side effects and unwanted, within which hypotension can occur.

If you are hypertensive , please consult your doctor. It is important that you evaluate the type of medication you are using to find out whether it is compatible with Cialis. You may be able to use medications such as nitrates but adjust the dosages very well and be aware of the effects. You may be told to stop using nitrate many hours before using tadalafil, however, it is best not to use this medication under these circumstances or to change your antihypertensive. Those who take medications such as Cardura or Hytrin for urinary symptoms cannot use Cialis.

You need to consult your doctor to see what options are available to you and how you can resolve your problem. Drug interactions: This medicine may alter the half-life and effectiveness of others. Your doctor should be aware of the drugs you take, even sporadically.

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Not only can they cause you harmful adverse effects, but you may simply not see any effect, due to the mechanism of action of Cialis. This also includes those you take as a supplement, and even common or over-the-counter medications. Storage: This is a delicate medicine that should always be stored and kept under supervision.

Try to keep the medication in its original container and name it. Keep at room temperature and in a dry place. Do not mix it with other tablets or put it somewhere with other medicines.

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The effect on children is much more potent and low blood pressure can cause death. In case you notice any alteration on the tablet, which is damaged or something similar, do not consume it. Do not dispose of the medicine by traditional means, keep it and consult with your pharmacist or doctor on how to dispose of it. Erectile dysfunction is perhaps the most important sexual disorder of the male gender. It is defined as the inability to achieve an ideal erection, rigid enough and firm enough to have satisfactory sexual relations.

Many doctors suggest that erectile dysfunction does not have to be an age-related disorder, which is not a disease that men simply must wait for at some point. Experts say it's a totally preventable disease, rooted in lack of care in general, but also in other external problems, such as traumatic accidents. Because of the definition given to this disorder, and its slightly subjective character, it is difficult to estimate the incidence and prevalence of this disease worldwide. As the disease became better known, and devices were developed to act on it, the numbers gradually increased.

Men felt more confident to go out and talk about their problem because they knew there was a solution. Therefore, numbers have been in constant evolution, and today a large population of people with erectile dysfunction is known. Under normal conditions, the penis has diminished or normal blood flow, which keeps the penis flaccid but with the necessary irrigation to perform the rest of its functions.

In principle, when sexual stimulation is received which can come from many different pathways, in which the senses or the mind are involved many signals are released that conclude in the increase of a fundamental molecule called Nitrous Oxide NO , which will mediate the whole process.

The secret of the whole erection is in one word, "Vasodilatation". With nitric oxide, one of the most powerful vasodilators in the entire body, the multiple arteries of the penis widen and allow more blood to flow through it, greatly increasing the volume. The secretion and constant local formation of this mediator are what gives way to a sustained erection.

As the penis enlarges, the veins, which do not have firm vascular walls, compress. This way the blood gets "stuck" in the penis. In theory, what we would have is an increase in blood flow from the inlet, with the outlet closed.

So, the penis only increases in volume and becomes stiffer. Erection is a phenomenon, as we mentioned, of purely neurovascular origin, but like everything else, it is subject to hormonal control. There are many factors involved, where the most important is Nitrous Oxide. There can be many causes that give way to the appearance of erectile dysfunction. They can be problems based on the body, traumatic events or the mind. Let's explain each of them step by step. These are related to anatomical problems, neurological, endocrine, etc..

Any problem that originates in the organism, either by external mechanisms drugs or alcohol or internal ones vascular, nervous, infectious disorders. In this classification, endocrine and vascular disorders stand out. Cardiovascular complications are usually the most frequent cause of erectile dysfunction. This is where patients with high-fat arteriosclerosis and obese patients come in. In this case, the disorder is in the production of nitric oxide by the destruction of the endothelium and vascular damage caused by that basal vascular damage.

As for diabetes, high concentrations of glucose in the blood can greatly decrease the amount of nitric oxide released from our arteries. Under both conditions, blood flow may be preserved, but endothelial damage will not allow an erection to develop. There is a separate classification for traumatic causes in the classification.

Here come some problems such as pelvic fractures, where there are also several anatomical problems that do not allow the erection to develop. As mentioned above, sexual stimulation plays a fundamental role in erection. It is necessary to emphasize it because even to have erections using drugs such as Sildenafil, it is necessary to have an initial sexual stimulus.

Even if you use the medication, if there is no stimulus, there will be no erection. In order to talk about psychological causes, the penis and the patient's body must be in good condition. Most of the time it is due to some effective or interpersonal disorders, such as depression or anxiety. However, it can oscillate and involve other problems such as infidelity or feelings of guilt.