RAR-gamma is associated with retinoid effects on mucocutaneous tissues and bone. Although the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes.
Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. Tretinoin is not a cytolytic agent but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given systemically to APL patients, tretinoin treatment produces an initial maturation of the primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood by normal, polyclonal hematopoietic cells in patients achieving complete remission CR.
The exact mechanism of action of tretinoin in APL is unknown. Confidence intervals for binomial parameters were computed using the method of Ghosh. Day 1 and day 15 values for each pharmacokinetic parameter concentration of tretinoin at the end of the infusion, tenninal-phase half-life [td], area under the curve of [AUC] of tretinoin concentration versus time, clearance of ATRA from blood, and volume of distribution with and without adjustment for body weight were compared using the Wilcoxon sign-rank test for paired data.
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Compare Atralin prices, print discount coupons, find manufacturer Atralin ( tretinoin topical) is a member of the topical acne agents drug class and is commonly. Tretinoin (Retin-A, Atralin, Avita) is a moderately priced drug used to treat acne and other skin conditions when applied topically. Generic tretinoin is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for.
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